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Cited by 15Skin Protection and AgingDNA Repair MechanismsEffects of Radiation Exposure

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Keratinocytes Exposed to Ultraviolet Radiation Reveal Three Down-regulated Genes with Potential Function in Differentiation and Cell Cycle Control

Pötter, Thomas, Göhde, Wolfgang, Wedemeyer, Niels, Köhnlein, Wolfgang·2000·Radiation Research
DOI 10.1667/0033-7587(2000)154[0151:keturr]2.0.co;2
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Abstract

The incidence of skin cancer is increasing in epidemic proportion. Although solar UV radiation is known to be the major risk factor, much information is lacking about the molecular mechanisms leading to skin cancer. To gain a deeper insight into these mechanisms, we have examined cells of a human keratinocyte cell line (HaCat) after exposure to 0.16 minimal erythema doses of UVB radiation. This dose led to an S-phase delay that was reversible 22 h postirradiation. To examine gene expression 10 h after UV irradiation, a nonradioactive differential display was employed. Three genes were identified as being down-regulated significantly. The first encodes for topoisomerase-IIbeta-binding protein 1 (expression level 5% 6 h after irradiation). This protein is associated with human topoisomerase IIbeta and appears to be necessary for DNA replication during the onset of S phase. The second gene product has previously been reported to be involved in differentiation and is therefore known as differentiation-dependent A4 protein (28% 8 h after irradiation). The third gene is XPO1 (also known as CRM1) (5% 8 h after irradiation), whose protein is involved in nuclear export of mRNA molecules. Differential expression of these genes after UV irradiation has not been reported. Because of their potential involvement in cell cycle control and differentiation, these proteins could be important for understanding the reaction of keratinocytes after exposure to UV radiation.

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Crossref · 10.1667/0033-7587(2000)154[0151:keturr]2.0.co;2

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Metadata

Authors
Pötter, T., Göhde, W., Wedemeyer, N., & Köhnlein, W.
Affiliations
University of Münster (DE)
Venue
Radiation Research
Publisher
Radiation Research Society
Published
2000-08
Volume
154
Issue
2
Pages
151-158
ISSN
  • 0033-7587 (ISSN-L)
  • 1938-5404
DOI
10.1667/0033-7587(2000)154[0151:keturr]2.0.co;2
OpenAlex
W2172514538
Cited by
15
References
40
Citations by year
2015: 2 · 2013: 1
FWCI
2.79
Type
journal article
Language
en
Open access
closed
Locations
  • Radiation Research (publishedVersion)
  • PubMed (publishedVersion)
  • BioOne Complete (BioOne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
keratinocytes, ultraviolet radiation, UV-B radiation, skin cancer, gene downregulation, topoisomerase II beta, CRM1, mRNA export, cell cycle regulation, S phase delay, HaCaT keratinocytes, DNA replication
MeSH terms
Exportin 1 Protein, Carrier Proteins, Cell Cycle, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Genes, Humans, Membrane Proteins, Nuclear Proteins, Proteolipids, Radiation Dosage, Ultraviolet Rays, RNA Probes, Down-Regulation, Keratinocytes, Polymerase Chain Reaction, Receptors, Cytoplasmic and Nuclear, Karyopherins, MARVEL Domain-Containing Proteins

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CoChat. (2026). Citation check: Keratinocytes Exposed to Ultraviolet Radiation Reveal Three Down-regulated Genes with Potential Function in Differentiation and Cell Cycle Control. https://app.cochat.ai/papers/10.1667/0033-7587(2000)154%5B0151:keturr%5D2.0.co;2
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Pötter, T., Göhde, W., Wedemeyer, N., & Köhnlein, W. (2000). Keratinocytes Exposed to Ultraviolet Radiation Reveal Three Down-regulated Genes with Potential Function in Differentiation and Cell Cycle Control. Radiation Research. https://doi.org/10.1667/0033-7587(2000)154%5B0151%3Aketurr%5D2.0.co%3B2

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